Table 2.
Distribution Characteristics of CRRT or Non-CRRT Final Model Estimation Parameters and Bootstrap Analysis
| Parameter | Non-CRRT* | CRRT | ||
|---|---|---|---|---|
| Final Model | Bootstrap Analysis | |||
| Estimate [RSE (%)] | Estimate [RSE (%)] | Median Estimate [RSE (%)] | 95% CI | |
| CL (L/h) | 3.09 (26.3) | 4.22 (10.4) | 4.27 (9.51) | 3.47–5.07 |
| V1 (L) | 32.1 (8.38) | 30.9 (15.9) | 31.6 (16.7) | 22.4–43.1 |
| Q (L/h) | 39.7 (5.79) | 34.8 (8.94) | 35.0 (9.25) | 29.4–42.3 |
| V2 (L) | 113 (4.61) | 98.7 (11.8) | 98.5 (10.9) | 78.4–120 |
| Inter-individual variability | ||||
| ωCL (%) | 27.0 (15.0) | 22.4 (31.6) | 20.7 (33.0) | 9.93–36.3 |
| ωV1 (%) | 72.5 (13.9) | 55.2 (25.4) | 52.7 (25.3) | 28.4–81.0 |
| Residual variability | ||||
| σ (%) | 2.02 (13.8) | 1.58 (15.7) | 1.52 (15.0) | 1.11–1.98 |
Notes: * Parameters of non-CRRT patients were derivate from Su et al, Front Pharm. 2024, 15: 1342954.
Abbreviations: CRRT, continuous renal replacement therapy; CL, typical value of apparent clearance; V1, central volume of distribution; Q, inter-compartmental clearance; V2, peripheral volume of distribution; ωCL, fixed-effect parameter of CL; ωV1, fixed-effect parameter of V1; σ, residual variability for proportional error; RSE, residual standard error; CI, confidence interval.