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. 2023 Nov 19;64:195–211. doi: 10.1016/j.jare.2023.11.021

Fig. 2.

Fig. 2

TBN increases mitochondrial function. (A) ECAR response curve. (B) Glycolysis, Glycolytic Capacity, and Glycolytic Reserve. (C) OCR response curve. (D) Non-mitochondrial oxygen consumption, spared respiratory capacity (%), and coupling efficiency (%). Data are mean ± SD of two independent experiments. Data were analyzed using a two-tailed unpaired Student’s t-test or Mann-Whitney test (C, D). (E) Basal respiration, maximal respiration, and ATP production. Data are mean ± SD of two independent experiments. Data were analyzed using the Mann-Whitney test. (F) The response curve of OCR after TBN treatment of MPP+-induced PC12 cells. (G) Basal respiration, maximal respiration, and ATP production. (H) ATP content (nmol/mg protein, % of Ctrl). (I) Mitochondrial complex I activity (% of Ctrl) in CGNs. Data are mean ± SD of three independent experiments. Data were analyzed using one-way ANOVA followed by Dunnett’s multiple comparisons test (G-I). *P < 0.05, **P < 0.01 and ***P < 0.001 versus untreated control group. #P < 0.05, ##P < 0.01 and ###P < 0.001 versus MPP+ alone group.