Table 4.
TBN pharmacokinetics in healthy Chinese volunteers after multiple-dose administration for 7 days.
| Dose (mg) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | Cmin (ng/mL) | Cavg (ng/mL) | CLss/F (ng/mL) | Vss/F (mL/h) | AUC0-tau (h·ng/mL) | |
|---|---|---|---|---|---|---|---|---|---|
| TBN | 600 | 1.89 | 3.38 | 9583.79 | 77.01 | 1979.82 | 32593.82 | 88828.76 | 23757.87 |
| 1200 | 2.30 | 2.56 | 25271.09 | 524.03 | 6775.17 | 17397.63 | 57710.15 | 81302.08 |
t1/2 = elimination half-life; Tmax = time to peak concentration; Cmax = maximum serum concentration; Cmin = steady state trough concentration; Cavg = average steady state concentration; Clss/F = steady state clearance; Vss/F = steady state volume of distribution; AUC0-tau = AUC at steady state during one dose interval.