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. 2024 Oct 9;10:432. doi: 10.1038/s41420-024-02195-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The modulation of ferroptosis can exert significant effects on RCC through various mechanisms, encompassing the regulation of GSH levels, lipid metabolism, iron metabolism, the NRF2 signaling pathway, the HIF-2α signaling pathway, and the ROS signaling pathway. Abbreviations: PUFAs, polyunsaturated fatty acids; CoA, coenzyme A; PL-PUFAs, phospholipid-containing PUFAs; ACSL4, acyl-CoA synthetase long-chain family member 4; LPCAT3, lysophosphatidylcholine acyltransferase 3; TF, transferrin; TFR1, transferrin receptor 1; STEAP3, iron oxide reductase steam 3; DMT1, divalent metal transporter 1; NCOA4, nuclear receptor coactivator 4; LIP, labile iron pool; SLC7A11, solute carrier family 7 member 11; SLC3A2, solute carrier family 3 member 2; GSH, glutathione; GSSG, Oxidized glutathione; GPX4, glutathione peroxidase 4; KLF, Kruppel-like factor; ICS II, Icariside II; DPP4, dipeptidyl-peptidase-4; NRF2, nuclear factor erythroid 2-related factor 2; OGT, O-GlcNAc transferase; HIF-2α, hypoxia-inducible factor-2α; SDH, succinate dehydrogenase; ROS, Reactive Oxygen Species.