Table 3.

The roles of ferroptosis in the treatment of urological malignancies.

Cancer	Drug	Target	Ferroptosis (inducer inhibitor)	Biological function	Model	Reference
RCC		KLF2	Induce	Suppress proliferation, migration and invasion abilities of RCC cells	In vitro and in vivo	[29]
		AIM2	Inhibit	Promote RCC progression and sunitinib resistance	In vitro and in vivo	[39]
		MLYCD	Induce	Reduce tumor growth and reverse resistance to sunitinib	In vitro and in vivo	[43]
		OGT	Induce	Promote the proliferation, clone formation, and invasion of VHL-mutated ccRCC cells	In vitro and in vivo	[48]
		Knockdown of SETD2	Induce	Promote tumor cell death	In vitro and in vivo	[103]
		STEAP3	Inhibit	Poor survival and prognosis	In vitro	[104]
	RSL3 or Erastin		Induce	Overcome resistance to everolimus	In vitro	[105]
	MIL-101(Fe)@RSL3		Induce		In vitro and in vivo	[107]
		NCOA4	Induce	Maintain ferritinophagy	In vitro and in vivo	[108, 109]
		CX3CL1	Induce	Inhibit tumor cell proliferation and metastasis	In vitro and in vivo	[110]
PCa	Flubendazole		Induce	Inhibit cell proliferation,cause cell cycle arrest in G2/M phase and promoted cell death	In vitro and in vivo	[51]
		PHGDH	Inhibit	Promote cell growth and Enza resistance in CRPC cells	In vitro and in vivo	[56]
	TQB3720		Induce	Inhibit the growth of prostate cancer	In vitro and in vivo	[59]
		AOC1	Induce	Reduce proliferation and migration in prostate cancer	In vitro and in vivo	[67]
	Erastin or RSL3		Induce	Halt prostate cancer cell growth and migration in vitro and tumor growth in vivo	In vitro and in vivo	[111]
	Icariin and curcumol		Induce	Induce autophagy in PCa cells	In vitro and in vivo	[113]
	Ferumoxytol		Induce	Enhance NK cells’ function	In vitro and in vivo	[114]
BCa	NCT-502	PHGDH	Inhibit	Induce tumor progression	In vitro and in vivo	[69]
		EMP1	Induce	Suppress tumor cell metastasis	In vitro and in vivo	[70]
	BQR@MLipo		Induce	Trigger ferroptosis of bladder cancer	In vitro and in vivo	[74]
		FLRT2	Induce	Suppress tumor cell growth, migration and invasion	In vitro	[76]
	Abietic acid (AA)		Induce	Selectively inhibited the viability of BC cells	In vitro and in vivo	[78]
		RP11-89	Inhibit	Promote cell proliferation, migration and tumorigenesis and inhibited cell cycle arrest	In vitro and in vivo	[117]
		LUCAT1	Inhibit	Foster cell proliferation, migration, and invasion	In vitro and in vivo	[119]
	Evodiamine		Induce	Suppress the migratory ability, decreas the expression of mesenchymal markers, and increase epithelial marker expression	In vitro and in vivo	[120]