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. 2024 Oct 9;15(10):734. doi: 10.1038/s41419-024-07089-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A, B DTL overexpression and knockdown stable cell line were established; the DTL mRNA and protein levels were determined by qRT-PCR and western blot. C The effect of DTL overexpression and knockdown on the cell cycle in Huh-7 and HCCLM-3 were analyzed by flow cytometry. D, E The effect of DTL overexpression and knockdown on proliferation in Huh-7 and HCCLM-3 cells was determined by Cell Counting Kit-8 (CCK-8) assays. F, G The effect of DTL overexpression and knockdown on proliferation in Huh-7 and HCCLM-3 cells was determined by clone formation assay. H The relative cell viability of DTL knockdown Huh-7 and HCCLM-3 cells after treatment with different concentrations of sorafenib for 72 h was detected by CCK-8 assays. I CCK-8 assays showed the proliferation of Huh-7 and HCCLM-3 cells response to 3 μM sorafenib with DTL knockdown. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significance.