Table 5.
Discrete hyper-reflective foci in participants with Stargardt disease.
| Participant | Eye | Eccentricity (degrees) | SW-FAF | NIR/NI-FAF | SD-OCT | Mean FWHM [SD] (µm) | |
|---|---|---|---|---|---|---|---|
| Min | Max | ||||||
| S02 | OD | 0.3 | 6.0 | Heterogeneous and hypo-AF | Heterogeneous NI reflectance | Disruption and/or loss of ELM and EZ | 4.4 [0.2] |
| S03 | OS | 4.0 | 4.0 | Heterogeneous AF | Heterogeneous NI reflectance | Loss of ELM and EZ | 4.3 [0] |
| S05 | OD | 3.4 | 7.0 | Heterogeneous AF | Reduced NI reflectance | Disruption and/or loss of ELM and EZ | 4.4 [0.4] |
| S06 | OD | 0.5 | 1.0 | Hypo-AF | Heterogeneous NI reflectance | Loss of ELM and EZ | 3.6 [0.2] |
| S09 | OS | 0.3 | 6.2 | Normal and hypo-AF | Heterogeneous NI reflectance in areas of normal SW-FAF | ONL thinning in areas of normal SW-FAF or hyper-reflective ELM and EZ loss | 4.3 [0.1] |
| S11 | OS | 13.4 | 18.4 | Heterogeneous AF | Heterogeneous AF | Loss of ELM and EZ | 3.4 [0.2] |
| S12 | OS | 5.9 | 8.0 | Hypo-AF | Hypo-AF | Hyper-reflective foci within ONL | 3.5 [0.2] |
| S14 | OS | 7.6 | 7.6 | Heterogeneous AF | Heterogeneous AF | Disruption of ELM and EZ | 4.3 [0] |
| S15 | OS | 10.5 | 10.9 | Heterogeneous AF | Hypo-AF | Disruption of ELM and EZ | 4.0 [0.1] |
NIR near infrared reflectance imaging. NI-FAF near-infrared fundus autofluorescence, OD right eye, OS left eye, SD-OCT spectral-domain optical coherence tomography, SW-FAF short-wavelength fundus autofluorescence.