TABLE 1.

Summary of bacterial non-hydrolyzing UDP-GlcNAc 2-epimerase structures in the PDB [modified after (Legg, 2022)].

PDB	Identity to MnaA (%)	Resolution	Organism	Conformation	Catalytic site substrate	Allosteric site substrate	References
3BEO	67.2	1.70 Å	Bacillus anthracis	Closed	UDP*	UDP-GlcNAc	Velloso et al. (2008)
1O6C	63.0	2.90 Å	Bacillus subtilis	Open	—	—	Badger et al. (2005)
4FKZ	63.0	1.69 Å	Bacillus subtilis	Closed	UDP*	UDP-GlcNAc	Structure released in 2013; no associated publication
3OT5	59.2	2.20 Å	Listeria monocytogenes	Open	—	—	Structure released in 2010; no associated publication
5ENZ	58.0	1.91 Å	Staphylococcus aureus	Closed	UDP*	—	Mann et al. (2016)
1F6D	53.8	2.50 Å	Escherichia coli	Partially open	UDP*	—	Campbell et al. (2000)
1VGV	53.8	2.31 Å	Escherichia coli	Closed-liganded	UDP-GlcNAc		(Badger et al., 2005) *
3DZC	50.7	2.35 Å	Vibrio cholerae	Open	—	—	Structure released in 2008; no associated publication
6VLB	48.1	1.85 Å	Neisseria meningitidis	Open	—	—	Hurlburt et al. (2020)
6VLC	48.1	2.15 Å	Neisseria meningitidis	Closed	UDP-GlcNAc	—	Hurlburt et al. (2020)
5DLD	47.8	1.45 Å	Burkholderia vietnamiensis	Closed	UDP*	UDP-GlcNAc	Structure released in 2015; no associated publication
1V4V	45.4	1.8 Å	Thermus thermophilus	Open	—	—	Structure released in 2003; no associated publication
4NEQ	32.1	2.85 Å	Methanocaldococcus jannaschii	Open	—	—	Chen et al. (2014)
4NES	32.1	1.42 Å	Methanocaldococcus jannaschii	Closed	UDP*	UDP-GlcNAc	Chen et al. (2014)
4HWG	29.5	2.00 Å	Rickettsia bellii	Open	—	—	Structure released in 2003; no associated publication
7VYY	38.9	2.44 Å	Streptomyces kasugaensis	Open			Rattinam et al. (2022)
7VZA	38.9	2.58 Å	Streptomyces kasugaensis	Closed	UDP*		Rattinam et al. (2022)
7VZ6	38.9	2.09 Å	Streptomyces kasugaensis	Closed	UDP-Glc		Rattinam et al. (2022)

* Only the UDP component of UDP-GlcNAc substrate was modeled in the catalytic site of the indicated structures.