Figure 4.

Dysregulation of PDK1 at protein expression and phosphorylation level for different sexes and time points of Alzheimer disease 5XFAD model

(A) Protein expression (log2-FC) of PDK1 for all time points and sexes.

(B) The auto-phosphorylation (log2-FC) of PDK1 for all time points and sexes.

(C) Inferred activity score of PDK1 for all time points and sexes.

(D) Phosphorylation (log2-FC) of known targets of PDK1 for 9 months’ data. For all plots, the coloring is done to reflect the degree of statistical significance based on Z scores.