Table 1.
Reactome pathways identified as significant in AD phospho-proteome for 3-/6-/9-month time points
| Pathway | # of Proteins | Z score | FDR | |
|---|---|---|---|---|
| 3 Month | Regulation of gap junction activity | 2/3 | 4.60 | 0.0019 |
| Cation-coupled chloride cotransporters | 2/7 | 4.13 | 0.0053 | |
| RHO GTPases activate PAKs | 10/20 | 3.34 | 0.08 | |
| DARPP-32 events | 7/16 | 3.31 | 0.08 | |
| RAF/MAP kinase cascade | 26/91 | −4.28 | 0.004 | |
| 6 Month | Regulation of gap junction activity | 2/3 | 3.59 | 0.021 |
| Scavenging by class A receptors | 2/7 | 8.64 | 0 | |
| EPH-ephrin-mediated repulsion of cells | 5/30 | 4.90 | 0.00021 | |
| Noncanonical activation of NOTCH3 | 2/5 | 4.62 | 0.00054 | |
| Nuclear signaling by ERBB4 | 2/9 | 4.21 | 0.0028 | |
| NRIF signals cell death from the nucleus | 2/10 | 4.10 | 0.029 | |
| CS/DS degradation | 2/7 | −3.37 | 0.0033 | |
| 9 Month | Regulation of gap junction activity | 2/3 | 5.41 | 1.4e-05 |
| Scavenging by class A receptors | 2/7 | 5.66 | 6.4e-06 | |
| Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | 4/12 | 4.83 | 0.00015 | |
| MTOR signaling | 5/14 | 3.71 | 0.006 | |
| Norepinephrine neurotransmitter release cycle | 8/15 | −4.10 | 0.0017 | |
| Dopamine neurotransmitter release cycle | 13/20 | −4.25 | 0.0015 | |
| GABA synthesis, release, reuptake, and degradation | 8/12 | −4.74 | 0.00018 |
Each row corresponds to a different pathway. Up to seven significant pathways are shown for each time point. “# of proteins” column indicates the number of proteins in the pathway; the first number is for proteins identified in our data, and the second one (after/) is for total number of proteins.