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. 2024 Oct 10;12:160. doi: 10.1186/s40478-024-01864-2

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — Correlations of analytes in serum and in cerebrospinal fluid of RRMS and age and sex matched control patients. Spearman correlation heatmaps of analytes of age and sex matched control (Ctrl; a, c) and relapsing remitting MS (RRMS; b, d) patients in serum (a, b) and in cerebrospinal fluid (CSF; c, d). For each pairwise correlation the Spearman r is shown in the heatmaps. The color-coding legend of the Spearman r values is presented at the bottom and reaches from − 1 (strong negative correlation, blue) over 0 (no correlation, white) to 1 (strong positive correlation, red). Significant correlations (p < 0.05) are highlighted with bold Spearman r values. The patient number, p-value and confidence interval of each pairwise Spearman correlation are presented in the Online Resource 2