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. 2024 Oct 10;24:643. doi: 10.1186/s12887-024-05116-z

Table 1.

Characteristics of the included studies (n=10)

Intervention Group Control Group Topical Anesthetic
Study, Year, Country N (Male Number) Age Range (mean) Health States of Participants Setting Needling Procedure Type of Social Robots Interactive Duration Whether Combined with CBT Specific Process / Pain Outcomes Reported  Measurement Time  Affective Outcomes
Beran et al, 2013, [19] Canada 57 (30) 4-9 (7) 23 children were under medical condition34 children were healthy Outpatient clinic Flu vaccination Humanoid: NAO During the procedure Yes Introduction, chatting, blowing technique, encouragment Minimal typical distraction / Self reported pain, observed pain (FPS-R) The strongest moment during procedure Behavioral measure of distress (BAADS)
Jibb et al,2018, [31] Canada 40 (24) 4-9 (6) Children with cancer Outpatient clinic Port needle insertion Humanoid: NAO (renamed MEDiPORT) During the procedure Yes Introduction, making supportive statements, deep breathing techniques, encouragement High-tech distraction Mandatory Self reported pain (FPS-R) Post procedure Behavioral measure of distress (BAADS)
Trost et al,2020, [14] USA 21 4-14 (10) Children who needed to receive MRI Radiology suite IV placement Humanoid: MAKI (renamed IVEY) During the procedure Yes Robot assisted the child life specialist: provide emotional support based on the child's expressed level, practice deep breathing The usual distraction provided by child life / Self reported pain, Behavioral measure of pain (Wong-Baker FACES scale, FLACC, CHEOPS) Before interaction, prior to IV placement, post procedure Self reported fear (CFS)
Kasimoglu et al, 2020, [34] Turkey 200 (98) 4-10 (7) Children who needed to receive MRI Dental clinic Dental treatment Humanoid: iRobiQ During the procedure Only distraction Singing, displaying animation, performing body movements with facial expressions Usual distraction Permitted but not mandatory (100/200) / / Self reported anxiety (FIS)
Kasimoglu et al, 2023, [33] Turkey 102(50) 4-10 (7) Children who needed pulpotomy Dental clinic Dental treatment Humanoid: NAO During the procedure Only distraction Performing targeted motor tasks to distract Nonverbal communication, distraction, positive encouragement, voice control, and tell-show-do Mandatory / / Self reported anxiety (FIS)
Ali et al, 2021, [21] Canada 86 (47) 6-11 (9) Children who had some acute diseases Emergency department IV placement Humanoid: NAO During the procedure Yes Introduction, chatting, deep breathing exercise, encouragement, dancing and Tai Chi Normal comforting techniques Permitted but not mandatory (78/86) Self reported pain (FPS-R) Before procedure, during procedure Behavioral measure of distress (OSBD-R)
Smakman et al,2021, [32] Netherlands 137 4-12 (8) Not mentioned Blood drawring policlinic Blood draw Humanoid: NAO During the procedure Only distraction Robots have three different programs based on ages to distract children1) Lower classes aged 4-6: introduction, singing, dancing and encouragement 2) Middle classes aged 6-9: introduction, Taichi, playing saxophone, telling jokes, dancing and encouraging 3) Higher classes aged 9-12: introduction, telling jokes, playing saxophone, dancing and encouraging Normal distraction techniques / Behavioral measure of pain (FLACC) Before procedure, during procedure, post procedure Self reported anxiety (VAS-A)
Lee-Krueger et al, 2021, [20] Canada 103 (57) 4-12 (8) Children with a systematic disease Surgery Short Stay Unit IV placement Humanoid: NAO (renamed MEDI) Before the procedure Yes Greeting, teaching deep breath, encouraging Other forms of pain management strategies  Mandatory Self reported pain, Observed pain (FPS-R) During proceduere Self reported fear (CFS)
Rheel et al, 2022, [29] Belgium 22 (10) 8-12 (9) Children with chronic disease Outpatient clinic IV placement/Port needle insertion Humanoid: NAO During the procedure Only distraction Playing quiz games, encouraging Minimal typical distraction Permitted but not mandatory (13/22) Self reported pain (FPS-R) Before procedure, post procedure Self reported fear (CFS)
Chang Ching-Yi, 2023, [30] Taipei, China 47 (23) 5-12 (7) Children with mild disease Inpatient clinic IV placement Humanoid (not to mention type) During the procedure and lasting for 40 minutes Yes Social robot using digital storytelling Video-based storytelling / / / Behavioral measure of anxiety (mYPAS)

FPS-R Faces Pain Scale-Revised, FLACC Face, Legs, Activity, Cry, and Consolability Scale, CHEOPS The Children's Hospital of Eastern Ontario Scale, BAADS Behavioral Approach-Avoidance Scale, CFS Children’s Fear Scale, FIS Face Image Scale, OSBDR Observed Scale of Behavioral Distress-Revised, VAS-A Visual Analogue Scale for Anxiety, mYPAS modified Yale Preoperative Anxiety Scale