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. 2024 Oct 10;24:643. doi: 10.1186/s12887-024-05116-z

Table 2.

GRADE evidence profile

Patient or population: young children (<18 years old)
Settings: interventions were delivered in the communist health system in Turkey, Canada, Netherlands, Taipei (China) and the USA
Intervention: socially assistive robots
Control: minimal typical distraction including digital and non-digital techniques
Certainty assessment № of patients Effect Certainty Importance
№ of studies Study design Risk of bias Inconsistency Indirectness Imprecision Other considerations Intervention Control Relative(95% CI) Absolute(95% CI)
Pain (assessed with: FPS-R, FLACC; Scale from: 0 to 10)
5 randomised trials seriousa not serious not serious seriousb,c none 175 172 - SMD 0.02 SD lower(0.81 lower to 0.78 higher) ⨁⨁◯◯Low CRITICAL
Anxiety (assessed with: FIS, VAS-A, mYPAS; Scale from: 0 to 10)
4 randomised trials seriousd not serious not serious seriousb none 247 239 - SMD 0.36 SD lower(0.64 lower to 0.09 lower) ⨁⨁◯◯Low IMPORTANT
Distress (assessed with: BAADS, OSBD-R; Scale from: 0 to 10)
3 randomised trials seriouse not serious not serious seriousb,f none 89 89 - SMD 0.67 SD lower(1.04 lower to 0.3 lower) ⨁⨁◯◯Low IMPORTANT
Fear (assessed with: CFS; Scale from: 0 to 10)
2 randomised trials seriousg not serious not serious seriousb,h none 51 62 - MD 0.38 higher(0.06 lower to 0.82 higher) ⨁⨁◯◯Low IMPORTANT

CI confidence interval, MD mean difference, SMD standardised mean difference

Explanations

a. Five included studies failed to be blind to the outcome assessors, and one study did not report the patients' demographic data. Thus, most of studies were judged to be at some concerns

b. The forest plot showed a wide confidence interval(CI)

c. Five studies with only 347 participants were included

d. One study did not characterized the randomization method it applied, and the other study did not report the patients' demographic data. Thus, two out of the four were judged to be at high risks of bias

e. Three studies failed to be blind to the outcome assessors, thus being judged as high risks of bias

f. Three studies with only 178 participants were included

g. Tho studies failed to be blind to the outcome assessors, thus being judged as high risks of bias

h. Two studies with only 113 participants were included