(A) Schematic of different domains in PfCSP. The major repeats of the NANP motif are shaded in gray and the interspersed minor repeats of the NVDP motif are shaded in blue. The location of the N-terminal junction region of the CSP-containing NPDP motif (shaded in red), which is referred to here as N Interface, is indicated. The portion of CSP included in RTS,S vaccine is indicated. Schedule of vaccination, CHMI, and serum draws tested for humoral immunity are shown for MAL092 and MAL102 (B), MAL068 (C), and MAL071 (D). *The MAL092 Adu1Fx group was not vaccinated on day 28.