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. Author manuscript; available in PMC: 2024 Oct 10.
Published in final edited form as: Hear Res. 2022 Dec 17;428:108678. doi: 10.1016/j.heares.2022.108678

Table 1.

Summary of the “GO: Biological Process” categories associated with germanium-induced hearing loss.

Biological Process Categories N TN EASE
Down-regulated (3827 classified genes)
 Mitochondrion 225 679 0.000
 Mitochondrial membrane 81 226 0.000
 Mitochondrial envelope 85 242 0.000
 Mitochondrial inner membrane 76 209 0.000
 Mitochondrial electron transport chain 14 27 0.000
 Mitochondrial ribosome 17 39 0.000
 Mitochondrial matrix 21 57 0.001
 Mitochondrial lumen 21 57 0.001
 NADH dehydrogenase activity 15 35 0.001
 NADH dehydrogenase (Quinone) activity 15 35 0.001
 NADH dehydrogenase (Ubiquinone) activity 15 35 0.001
 Tricarboxylic acid cycle 10 20 0.004
 Acetyl-CoA catabolism 10 21 0.005
 Oxidative phosphorylation 17 51 0.010
 Acetyl-CoA metabolism 12 31 0.012
 ATP binding 184 99 0.049
Up-regulated (3327 classified genes)
 Transcription, DNA-dependent 289 1418 0.000
 Regulation of transcription, DNA-dependent 283 1397 0.000
 Ligase activity 71 293 0.001
 Endocytosis 35 1540 0.002
 Apoptosis 88 433 0.018
 Programmed cell death 88 439 0.025

Column titles: N, the number of identified genes in the category; FC, fold change; TN, the total number of genes in the category on the Gene Chip; EASE, EASE test score.