Table 3.
Associations between the components of LE8 and low thyroid function.
| Components of LE8 | Cases/participants | OR(95%CI) | P-value |
|---|---|---|---|
| HEI-2015 diet score | |||
| Low (0-49) | 618/3,157 | 1.000 (Reference) | |
| Moderate (50-79) | 349/1,578 | 1.126 (0.967, 1.311) | 0.12535 |
| High (80-100) | 408/1,580 | 1.245 (1.070, 1.449) | 0.00457 |
| Per 10-point increase | 1,375/6,315 | 1.260 (1.083, 1.465) | 0.00279 |
| Physical activity score | |||
| Low (0-49) | 497/1,875 | 1.000 (Reference) | |
| Moderate (50-79) | 58/223 | 1.005 (0.727, 1.388) | 0.97776 |
| High (80-100) | 820/4,217 | 0.705 (0.615, 0.807) | <0.00001 |
| Per 10-point increase | 1,375/6,315 | 0.965 (0.952, 0.979) | <0.00001 |
| Nicotine exposure score | |||
| Low (0-49) | 303/1,725 | 1.000 (Reference) | |
| Moderate (50-79) | 325/1,367 | 1.146 (0.949, 1.384) | 0.15700 |
| High (80-100) | 747/3,223 | 1.359 (1.159, 1.593) | 0.00016 |
| Per 10-point increase | 1,375/6,315 | 1.033 (1.016, 1.050) | 0.00011 |
| Sleep health score | |||
| Low (0-49) | 239/1,159 | 1.000 (Reference) | |
| Moderate (50-79) | 290/1,480 | 0.920 (0.756, 1.119) | 0.40373 |
| High (80-100) | 846/3,676 | 1.032 (0.873, 1.220) | 0.70914 |
| Per 10-point increase | 1,375/6,315 | 1.009 (0.985, 1.033) | 0.47804 |
| Body mass index score | |||
| Low (0-49) | 564/2,333 | 1.000 (Reference) | |
| Moderate (50-79) | 446/2,176 | 0.755 (0.653, 0.873) | 0.00014 |
| High (80-100) | 365/1,806 | 0.750 (0.643, 0.876) | 0.00027 |
| Per 10-point increase | 1,375/6,315 | 0.957 (0.939, 0.975) | <0.00001 |
| Blood lipids score | |||
| Low (0-49) | 549/2,310 | 1.000 (Reference) | |
| Moderate (50-79) | 333/1,472 | 0.996 (0.850, 1.167) | 0.96510 |
| High (80-100) | 493/2,533 | 0.778 (0.675, 0.896) | 0.00049 |
| Per 10-point increase | 1,375/6,315 | 0.964 (0.945, 0.983) | 0.00022 |
| Blood glucose score | |||
| Low (0-49) | 310/1,182 | 1.000 (Reference) | |
| Moderate (50-79) | 322/1,457 | 0.838 (0.697, 1.007) 0.05973 | 0.06973 |
| High (80-100) | 743/3,676 | 0.779 (0.660, 0.919) 0.00308 | 0.01094 |
| Per 10-point increase | 1,375/6,315 | 0.970 (0.948, 0.992) | 0.00908 |
| Blood pressure score | |||
| Low (0-49) | 485/1,814 | 1.000 (Reference) | |
| Moderate (50-79) | 408/2,004 | 0.775 (0.662, 0.909) | 0.00167 |
| High (80-100) | 482/2,497 | 0.742 (0.634, 0.869) | 0.00021 |
| Per 10-point increase | 1,375/6,315 | 0.965 (0.947, 0.983) | 0.00020 |
ORs and 95% CIs were adjusted for age strata, sex, race/ethnicity, education level, marital status, and UIC.
LE8, Life’s Essential 8; UIC, urine iodine concentration; OR, odds ratio; CI, confidence interval.