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. 2024 Sep 16;25(10):4153–4167. doi: 10.1038/s44319-024-00260-0

Figure 1. Emerging functions of amplified centrosomes in health and disease.

Figure 1

(A) Alterations in centrosome numbers can be associated with tumorigenesis and metastasis, as well as autosomal dominant polycystic kidney and liver disease (B) Amplified centrosomes can also appear naturally during terminal differentiation into highly specialized cell types, where they enhance specific effector functions such as ciliogenesis and innate immune processes thus questioning whether CA necessarily poses a risk to human health.