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. 2024 Sep 16;25(10):4153–4167. doi: 10.1038/s44319-024-00260-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Variation of centrosome numbers is important during development and differentiation, giving rise to cells that contain either no centrosomes or multiple. Centriole elimination (A) is observed in somatic cells of flies, C. elegans and some types of vertebrate and mammalian tissues, for instance in early embryogenesis, neurons, keratinocytes, myotubes or after whole-genome duplication in cardiomyocytes. On the other hand, CA (B) has been shown to regulate T cell priming and persistent locomotion of dendritic cells to chemotactic cues, efferocytosis in microglia, bone resorption capacity in osteoclasts, proplatelet formation in megakaryocytes and has also been observed in polyploid hepatocytes.