FIG. 6.

Models of C-terminal interactions between LMP2 proteins. (A) Association between LMP2A and the CD2 chimeric transmembrane proteins with the LMP2 C-terminal domain. (B) Interaction of the GST-LMP2 CT constructs. (C) The interactions involve two C-terminal domains, since the GST-LMP2A CT fusion protein can pull down the CD2-LMP2A C-terminal chimera from cell lysates of 3-5 cells. While we show that these interactions occur as tail-tail interactions, we cannot exclude that head-tail interactions might also occur. (D) Hypothetical interaction between LMP2 proteins through their shared C-terminal domains.