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Serum stability of STI-8811 in rat, cynomolgus monkey, and human serum determined by the percentage of payload release over 21 days (n = 3)
| Species | Concentration tested | % payload released |
|---|---|---|
| Rat | 100 μg/mL | 0.83% |
| Cynomolgus monkey | 0.22% | |
| Human | 0.54% | |
| 0.5% BSA PBS | 0.13% |
Payload concentration was measured by LC-MS/MS and converted to the percentage of the total ADC payload.
