Table I.
Baseline characteristics of included patients, and lesions characteristics.
| Epidemiology characteristics | Value | n | Percentage (%) |
|---|---|---|---|
| Age (years) | . | ||
| Mean | 63±10.5 | ||
| <65 | 92 | 55 | |
| ≥65 | 75 | 45 | |
| Gender | |||
| Male | 111 | 66 | |
| Female | 56 | 34 | |
| Median KPS | 80 (70–90) | ||
| Tumor characteristics | |||
| Mean FLAIR volume, cm3 | 98.3±59.2 | ||
| Mean T1-CE volume, cm3 | 34.5±26.7 | ||
| Satellite FLAIR lesions | 28 | 17 | |
| Genetics (sample size) | |||
| MGMT met (134) | 49 | 37 | |
| Mean Ki67 (136) | 31±18 | ||
| Mean p53 (138) | 20±24 | ||
| Extent of resection (n=167) | |||
| Complete | 69 | 41 | |
| Near total | 51 | 31 | |
| Partial | 13 | 8 | |
| Subtotal | 34 | 20 | |
| Postoperative protocol (n=149) | |||
| Completed concurrent RT/TMZ | 115 | 77 | |
| RT only/incomplete RT/TMZ | 34 | 23 | |
| Adjuvant treatments (n=129) | |||
| Adjuvant TMZ | 107 | 83 | |
| 6 cycles | 54 | 42 | |
| 12 cycles | 9 | 7 | |
| Mean preoperative blood test markers | |||
| PLT, ×109/l | 240±78.7 | ||
| MPV, ×10−15 l | 10.3±0.98 | ||
| PT ratio | 1.01±0.11 | ||
| aPTT ratio | 0.94±0.10 | ||
| Overall survival | |||
| Dead | 129 | 77 | |
| Alive | 38 | 23 |
Values are expressed as numbers and percentages (%). Continuous variables are shown as median (interquartile range) or mean ± standard deviation, according to the normality of distribution. MGMT met: MGMT methylation status. PLT, platelet counts; MPV, mean platelet volume; RT, radiotherapy; TMZ, temozolomide.