Table 1.

Mean (± SD) bovine plasma pharmacokinetic parameters of edoxaban during in vitro CRRT determined via noncompartmental analyses

CRRT modality	Cmax (mg/L)	t1/2 (h)	Vd (L)	CLCRRT (L/h)	AUC∞ (mg·h/L)	AUClast (mg·h/L)	AUC24 (mg·h/L)
CVVH	HF1400
2 L/h, 50/50%	0.34 ± 0.02	1.08 ± 0.03	2.35 ± 0.16	2.37 ± 0.09	0.278 ± 0.01	0.134 ± 0.01	3.229 ± 0.19
2 L/h, 100/0%	0.31 ± 0.05	0.90 ± 0.00	2.40 ± 0.43	2.93 ± 0.50	0.228 ± 0.04	0.125 ± 0.02	3.012 ± 0.56
2 L/h, 0/100%	0.28 ± 0.06	1.29 ± 0.23	2.59 ± 0.31	2.19 ± 0.15	0.300 ± 0.02	0.129 ± 0.01	3.100 ± 0.24
4 L/h, 50/50%	0.28 ± 0.04	0.60 ± 0.08	2.28 ± 0.36	4.08 ± 0.09	0.161 ± 0.00	0.110 ± 0.01	2.645 ± 0.25
CVVH				M150
2 L/h, 50/50%	0.31 ± 0.02	0.98 ± 0.18	1.82 ± 0.26	2.10 ± 0.66	0.329 ± 0.10	0.172 ± 0.04	4.122 ± 0.91
2 L/h, 100/0%	0.27 ± 0.01	0.93 ± 0.00	2.08 ± 0.18	2.40 ± 0.20	0.274 ± 0.02	0.145 ± 0.01	3.493 ± 0.32
2 L/h, 0/100%	0.38 ± 0.04	0.88 ± 0.02	1.57 ± 0.04	1.92 ± 0.09	0.342 ± 0.02	0.189 ± 0.01	4.532 ± 0.16
4 L/h, 50/50%	0.39 ± 0.09	0.52 ± 0.03	1.81 ± 0.57	3.87 ± 1.07	0.176 ± 0.05	0.131 ± 0.04	3.159 ± 0.09
CVVHD				HF1400
2 L/h	0.36 ± 0.04	0.87 ± 0.00	1.89 ± 0.21	2.38 ± 0.28	0.278 ± 0.03	0.155 ± 0.02	3.722 ± 0.37
4 L/h	0.38 ± 0.02	0.55 ± 0.00	1.74 ± 0.15	3.49 ± 0.40	0.189 ± 0.02	0.136 ± 0.01	3.261 ± 0.30
CVVHD				M150
2 L/h	0.40 ± 0.04	0.87 ± 0.09	1.37 ± 0.22	1.71 ± 0.08	0.385 ± 0.02	0.218 ± 0.03	5.220 ± 0.64
4 L/h	0.39 ± 0.04	0.49 ± 0.02	1.32 ± 0.23	2.94 ± 0.43	0.226 ± 0.03	0.173 ± 0.03	4.145 ± 0.68