Table 4.
Univariate and multivariate analyses of predictors of acute exacerbation for 240 patients with idiopathic interstitial pneumonia
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% confidence interval | P-value | Hazard ratio | 95% confidence interval | P-value | |
| Sex (male) | 1.277 | 0.559–2.918 | 0.562 | 1.597 | 0.529–4.831 | 0.407 |
| Age at initial visit | 1.046 | 0.992–1.102 | 0.100 | 1.052 | 0.996–1.112 | 0.069 |
| Smoking history (BI > 100) | 0.863 | 0.404–1.844 | 0.704 | 0.778 | 0.275–2.208 | 0.637 |
| ILD pattern (UIP) | 0.758 | 0.320–1.800 | 0.531 | 0.778 | 0.386–2.577 | 0.996 |
| Jo-1 | 0.049 | 0 | 0.893 | 0.000 | 0 | 0.997 |
| EJ | 0.049 | 0–263,571 | 0702 | 0.000 | 0 | 0.99 |
| OJ | 1.551 | 0.210–11.471 | 0.667 | 1.321 | 0.158–10.989 | 0.797 |
| PL-7 | 3.358 | 1.265–8.909 | 0.015 | 3.268 | 1.064–10 | 0.039 |
| PL-12 | 7.532 | 2.824–20.088 | 0.001> | 5.747 | 1.894–7.544 | 0.002 |
| SRP | 1.720 | 0.406–7.288 | 0.461 | 2.070 | 0.457–9.346 | 0.345 |
| Mi-2 | 0.047 | 0–289 | 0.492 | 0.000 | 0 | 0.984 |
BI, Brinkman Index; ILD, interstitial lung disease; UIP, usual interstitial pneumonia
Multivariate analysis was performed using models with variables selected a priori (sex and age at the initial visit, smoking history with Brinkman Index > 100), ILD pattern with UIP, MSA (Jo-1, EJ, OJ, PL-7, PL-12, SRP, and Mi-2). Bold values are statistically significant (P < 0.05)