Figure 3.

Physicochemical characterization of liposomes and hybrids. A) Nanoparticle size as determined by DLS. B) Polydispersity index of nanoparticles as determined by DLS. C) Zeta potential of nanoparticles as determined by laser Doppler electrophoresis. D) RNA encapsulation efficiency of liposomes and hybrids. E) Nanoparticle size as determine by NTA. Nanoparticle morphology as determined by cryogenic electron microscopy of F) liposomes, G) hybrids (1:100), and H) hybrids (1:50). Mean + SD are displayed. n = 8–10 (biological replicates), one‐way ANOVA with Tukey's post‐test, ns = not significant, ^** p < 0.01, ^*** p < 0.001, and ^**** p < 0.0001.