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The microbiota‐immunity‐CNS communication. This graphic representation shows the bioengineering approaches used to reproduce the main in vivo immune‐stimulated interfaces during neuroinflammation and neurodegeneration. The most advanced approach used to recapitulate each interface is the organ‐on‐a‐chip technology (OOC) based on microfluidic multi‐cell culture. (Image created with BioRender.com).
