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p21cip1 is involved in the cell cycle arrest induced by MVMp infection. The requirement of p21cip1 and p53 in the MVMp-induced cell cycle arrest was investigated in primary MEFs (MEFp) derived from either wild-type (wt), p21cip1-null (P21°), or p53-null (P53°) embryos. Cells were infected with MVMp or mock treated, harvested 24 h later, and processed for flow cytometric analysis of DNA contents. Bars represent the percentage of cells in the G0/G1, S, and G2/M phases of the cell cycle.
