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. 2022 Dec 9;12(6):2202412. doi: 10.1002/adhm.202202412

Figure 7.

Figure 7

QTPlus‐AM21 regulated macrophage to inhibit tumor growth in vitro. Mouse MC38 cells and RAW264.7 cells were co‐cultured with a fixed macrophage‐to‐tumor cell ratio of 3/1 followed by treatment with 400 nm of QTPlus‐AM21 overnight in the presence of or absence of LPS for M1 polarization. A) RAW264.7 cells treated with QTPlus‐AM21 inhibited wound‐healing by MC38 colorectal cancer cells; B) QTPlus‐AM21 regulated RAW264.7 cells to enhance apoptosis in MC38 cells. QTPlus‐AM21 induced C) macrophage proliferation and D) polarization to M1 population. The green line in (B) indicates the plot differences in fluorescent intensity of FITC‐conjugated Annexin V from the untreated group to QTPlus‐AM21 group. Student's t‐test was performed to determine the statistical differences between QTPlus‐AM21 group versus the untreated in the presence of LPS (n = 3). *p < 0.05, **p < 0.01.