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. 2022 Dec 9;12(6):2202412. doi: 10.1002/adhm.202202412

Figure 10.

Figure 10

Gene expression of cytokines and immune checkpoints in MC38 tumor‐bearing mice treated with QTPlus Ctrl and 3 mg kg−1 QTPlus‐AM21. In MC38 syngeneic mouse model, QTPlus‐AM21 induced A) CXCL10, IFNa, and TNFa in spleen tissues. QTPlus and QTPlus‐AM21 regulated PD‐1/PD‐L1 expression in B) tumor and C) spleen tissues (n = 3). Student's t‐test was performed to determine the statistical differences in CXCL10, IFNa, and TNFa expressions between QTPlus‐AM21 3 mg kg−1 group versus saline group. *p < 0.05, ***p < 0.001.