Table 2.
Detectable proteins in mECM previously and after decellularization process
| Protein name | mECM | mdECM |
|---|---|---|
| Collagens | ||
| Collagen alpha‐1(I) chain OS = Homo sapiens GN = COL1A1 PE = 1 SV = 5 | X | X |
| Collagen alpha‐2(I) chain OS = Homo sapiens GN = COL1A2 PE = 1 SV = 7 | X | X |
| Collagen alpha‐1(IV) chain OS = Homo sapiens GN = COL4A1 PE = 1 SV = 3 | X | X |
| Collagen alpha‐2(IV) chain OS = Homo sapiens GN = COL4A2 PE = 1 SV = 4 | X | X |
| Collagen alpha‐3(VI) chain OS = Homo sapiens GN = COL6A3 PE = 1 SV = 5 | X | X |
| Collagen alpha‐1(III) chain OS = Homo sapiens GN = COL3A1 PE = 1 SV = 4 | X | X |
| Collagen alpha‐2(V) chain OS = Homo sapiens GN = COL5A2 PE = 1 SV = 3 | X | X |
| Collagen alpha‐1(V) chain OS = Homo sapiens GN = COL5A1 PE = 1 SV = 3 | X | X |
| Collagen alpha‐1(VI) chain OS = Homo sapiens OX = 9606 GN = COL6A1 PE = 1 SV = 3 | X | X |
| Collagen alpha‐2(VI) chain OS = Homo sapiens OX = 9606 GN = COL6A2 PE = 1 SV = 4 | X | X |
| Collagen alpha‐1(VIII) chain OS = Homo sapiens GN = COL8A1 PE = 1 SV = 2 | X | X |
| Collagen alpha‐1(XII) chain OS = Homo sapiens OX = 9606 GN = COL12A1 PE = 1 SV = 2 | X | X |
| Collagen alpha‐1(VII) chain OS = Homo sapiens GN = COL7A1 PE = 1 SV = 2 | X | X |
| Collagen alpha‐2(VIII) chain OS = Homo sapiens GN = COL8A2 PE = 1 SV = 2 | X | |
| Collagen alpha‐1(XI) chain OS = Homo sapiens GN = COL11A1 PE = 1 SV = 4 | X | X |
| Collagen alpha‐1(XIV) chain OS = Homo sapiens GN = COL14A1 PE = 1 SV = 3 | X | X |
| Collagen alpha‐1(XVI) chain OS = Homo sapiens GN = COL16A1 PE = 1 SV = 2 | X | X |
| Collagen alpha‐1(XXI) chain OS = Homo sapiens GN = COL21A1 PE = 2 SV = 1 | X | |
| Glycoproteins | ||
| Fibulin‐1 OS = Homo sapiens GN = FBLN1 PE = 1 SV = 4 | X | X |
| Fibulin‐2 OS = Homo sapiens GN = FBLN2 PE = 1 SV = 2 | X | X |
| Filamin‐A OS = Homo sapiens OX = 9606 GN = FLNA PE = 1 SV = 4 | X | X |
| EMILIN‐1 OS = Homo sapiens OX = 9606 GN = EMILIN1 PE = 1 SV = 3 | X | X |
| EMILIN‐2 OS = Homo sapiens GN = EMILIN2 PE = 1 SV = 3 | X | X |
| Fibronectin OS = Homo sapiens OX = 9606 GN = FN1 PE = 1 SV = 4 | X | X |
| Fibromodulin OS = Homo sapiens GN = FMOD PE = 1 SV = 2 | X | X |
| Cartilage oligomeric matrix protein OS = Homo sapiens GN = COMP PE = 1 SV = 2 | X | X |
| Cartilage intermediate layer protein 1 OS = Homo sapiens GN = CILP PE = 1 SV = 4 | X | X |
| Cartilage intermediate layer protein 2 OS = Homo sapiens GN = CILP2 PE = 2 SV = 2 | X | X |
| Chitinase‐3‐like protein 1 OS = Homo sapiens GN = CHI3L1 PE = 1 SV = 2 | X | X |
| Periostin OS = Homo sapiens GN = POSTN PE = 1 SV = 2 | X | X |
| Thrombospondin‐1 OS = Homo sapiens GN = THBS1 PE = 1 SV = 2 | X | X |
| Thrombospondin‐2 OS = Homo sapiens GN = THBS2 PE = 1 SV = 2 | X | X |
| Tenascin OS = Homo sapiens OX = 9606 GN = TNC PE = 1 SV = 3 | X | X |
| Laminin subunit beta‐2 OS = Homo sapiens GN = LAMB2 PE = 1 SV = 2 | X | X |
| Laminin subunit alpha‐4 OS = Homo sapiens GN = LAMA4 PE = 1 SV = 4 | X | X |
| Laminin subunit gamma‐1 OS = Homo sapiens GN = LAMC1 PE = 1 SV = 3 | X | X |
| SPARC OS = Homo sapiens GN = SPARC PE = 1 SV = 1 | X | X |
| EGF‐containing fibulin‐like extracellular matrix protein 1 OS = Homo sapiens GN = EFEMP1 PE = 1 SV = 2 | X | X |
| EGF‐containing fibulin‐like extracellular matrix protein 2 OS = Homo sapiens GN = EFEMP2 PE = 1 SV = 3 | X | X |
| Vitronectin OS = Homo sapiens GN = VTN PE = 1 SV = 1 | X | X |
| Lactadherin OS = Homo sapiens GN = MFGE8 PE = 1 SV = 2 | X | X |
| Podocan OS = Homo sapiens GN = PODN PE = 1 SV = 2 | X | X |
| Olfactomedin‐like protein 3 OS = Homo sapiens GN = OLFML3 PE = 2 SV = 1 | X | X |
| Secretoglobin family 1D member 2 OS = Homo sapiens GN = SCGB1D2 PE = 2 SV = 1 | X | X |
| Semaphorin‐3C OS = Homo sapiens GN = SEMA3C PE = 2 SV = 2 | X | X |
| Thyroglobulin OS = Homo sapiens GN = TG PE = 1 SV = 5 | X | X |
| Proteoglycans | ||
| Basement membrane‐specific heparan sulfate proteoglycan core protein OS = Homo sapiens GN = HSPG2 PE = 1 SV = 4 | X | X |
| Biglycan OS = Homo sapiens OX = 9606 GN = BGN PE = 1 SV = 2 | X | X |
| Versican core protein OS = Homo sapiens OX = 9606 GN = VCAN PE = 1 SV = 3 | X | X |
| Decorin OS = Homo sapiens GN = DCN PE = 1 SV = 1 | X | X |
| Lumican OS = Homo sapiens GN = LUM PE = 1 SV = 2 | X | X |
| Mimecan OS = Homo sapiens GN = OGN PE = 1 SV = 1 | X | X |
| Regulators | ||
| Matrix metalloproteinase‐14 OS = Homo sapiens GN = MMP14 PE = 1 SV = 3 | X | X |
| A disintegrin and metalloproteinase with thrombospondin motifs 4 OS = Homo sapiens GN = ADAMTS4 PE = 1 SV = 3 | X | X |
| A disintegrin and metalloproteinase with thrombospondin motifs 3 OS = Homo sapiens GN = ADAMTS3 PE = 2 SV = 4 | X | X |
| A disintegrin and metalloproteinase with thrombospondin motifs 2 OS = Homo sapiens GN = ADAMTS2 PE = 2 SV = 2 | X | X |
| Metalloproteinase inhibitor 1 OS = Homo sapiens GN = TIMP1 PE = 1 SV = 1 | X | X |
| Metalloproteinase inhibitor 3 OS = Homo sapiens GN = TIMP3 PE = 1 SV = 2 | X | X |
| 72 kDa type IV collagenase OS = Homo sapiens GN = MMP2 PE = 1 SV = 2 | X | X |
| Interstitial collagenase OS = Homo sapiens GN = MMP1 PE = 1 SV = 3 | X | X |
| Matrix‐remodeling‐associated protein 5 OS = Homo sapiens GN = MXRA5 PE = 2 SV = 3 | X | X |
| Matrix‐remodeling‐associated protein 7 OS = Homo sapiens GN = MXRA7 PE = 1 SV = 1 | X | |
| Cell migration‐inducing and hyaluronan‐binding protein OS = Homo sapiens GN = CEMIP PE = 1 SV = 2 | X | X |
| 14‐3‐3 protein epsilon OS = Homo sapiens GN = YWHAE PE = 1 SV = 1 | X | X |
| 14‐3‐3 protein zeta/delta OS = Homo sapiens GN = YWHAZ PE = 1 SV = 1 | X | X |
| 14‐3‐3 protein beta/alpha OS = Homo sapiens GN = YWHAB PE = 1 SV = 3 | X | X |
| 14‐3‐3 protein theta OS = Homo sapiens GN = YWHAQ PE = 1 SV = 1 | X | X |
| 14‐3‐3 protein gamma OS = Homo sapiens GN = YWHAG PE = 1 SV = 2 | X | X |
| 14‐3‐3 protein eta OS = Homo sapiens GN = YWHAH PE = 1 SV = 4 | X | X |
| Collagen triple helix repeat‐containing protein 1 OS = Homo sapiens GN = CTHRC1 PE = 1 SV = 1 | X | X |
| Dermcidin OS = Homo sapiens GN = DCD PE = 1 SV = 2 | X | X |
| Serine protease HTRA1 OS = Homo sapiens GN = HTRA1 PE = 1 SV = 1 | X | |
| ECM‐affiliated proteins | ||
| Latent‐transforming growth factor beta‐binding protein 1 OS = Homo sapiens GN = LTBP1 PE = 1 SV = 4 | X | X |
| Prolargin OS = Homo sapiens GN = PRELP PE = 1 SV = 1 | X | X |
| Microfibrillar‐associated protein 2 OS = Homo sapiens GN = MFAP2 PE = 2 SV = 1 | X | X |
| Microfibrillar‐associated protein 5 OS = Homo sapiens GN = MFAP5 PE = 1 SV = 1 | X | X |
| Transforming growth factor‐beta‐induced protein ig‐h3 OS = Homo sapiens GN = TGFBI PE = 1 SV = 1 | X | X |
| Cartilage‐associated protein OS = Homo sapiens GN = CRTAP PE = 1 SV = 1 | X | X |
| Procollagen C‐endopeptidase enhancer 1 OS = Homo sapiens GN = PCOLCE PE = 1 SV = 2 | X | X |
| Annexin A6 OS = Homo sapiens GN = ANXA6 PE = 1 SV = 3 | X | X |
| Annexin A2 OS = Homo sapiens GN = ANXA2 PE = 1 SV = 2 | X | X |
| Annexin A5 OS = Homo sapiens GN = ANXA5 PE = 1 SV = 2 | X | X |
| Annexin A1 OS = Homo sapiens GN = ANXA1 PE = 1 SV = 2 | X | X |
| Annexin A4 OS = Homo sapiens GN = ANXA4 PE = 1 SV = 4 | X | |
| Annexin A7 OS = Homo sapiens GN = ANXA7 PE = 1 SV = 3 | X | |
| Annexin A11 OS = Homo sapiens GN = ANXA11 PE = 1 SV = 1 | X | |
| Galectin‐1 OS = Homo sapiens GN = LGALS1 PE = 1 SV = 2 | X | X |
| Galectin‐3 OS = Homo sapiens GN = LGALS3 PE = 1 SV = 5 | X | X |
| Protein CYR61 OS = Homo sapiens GN = CYR61 PE = 1 SV = 1 | X | X |
| Secreted factors | ||
| Myeloid‐derived growth factor OS = Homo sapiens GN = MYDGF PE = 1 SV = 1 | X | |
| Insulin‐like growth factor 2 mRNA‐binding protein 2 OS = Homo sapiens GN = IGF2BP2 PE = 1 SV = 2 | X | X |
| Hepatoma‐derived growth factor OS = Homo sapiens GN = HDGF PE = 1 SV = 1 | X | |
| Connective tissue growth factor OS = Homo sapiens GN = CTGF PE = 1 SV = 2 | X | |
| Guanylate‐binding protein 1 OS = Homo sapiens GN = GBP1 PE = 1 SV = 2 | X | |
| Pentraxin‐related protein PTX3 OS = Homo sapiens GN = PTX3 PE = 1 SV = 3 | X | X |
| Leukocyte elastase inhibitor OS = Homo sapiens GN = SERPINB1 PE = 1 SV = 1 | X | |
| Mesencephalic astrocyte‐derived neurotrophic factor OS = Homo sapiens GN = MANF PE = 1 SV = 3 | X | |
| Spondin‐1 OS = Homo sapiens GN = SPON1 PE = 1 SV = 2 | X | |
| Sushi repeat‐containing protein SRPX OS = Homo sapiens GN = SRPX PE = 1 SV = 1 | X | X |
| Sushi repeat‐containing protein SRPX2 OS = Homo sapiens GN = SRPX2 PE = 1 SV = 1 | X | X |