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. 2024 Oct 11;19:89. doi: 10.1186/s13062-024-00525-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 2 — The effect of overexpression or silencing of SAMHD1 on the tumor growth of endometrial cancer cells in nude mice Note (A) Morphology and volume of subcutaneously transplanted tumors in each group were observed; (B) The weight of subcutaneously transplanted tumors in each group was measured; (C) Expression of SAMHD1 in subcutaneously transplanted tumors of each group was detected by qRT-PCR; (D) Morphology of subcutaneously transplanted tumors in each group was assessed by H&E staining; (E) The rate of cell apoptosis in subcutaneously transplanted tumors of each group was determined by TUNEL staining; (F) Expression of Ki67 protein in subcutaneously transplanted tumors of each group was detected by Ki67 staining (50 μm). Purple * indicates a significant difference compared to the oe-NC group (p < 0.05), blue * indicates a significant difference compared to the sh-NC group (p < 0.05) (the data are presented as mean ± standard deviation. Group comparisons were conducted using one-way analysis of variance, while repeated measures analysis of variance was employed for comparisons across different time points)