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. 2024 Oct 11;19:89. doi: 10.1186/s13062-024-00525-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 5 — SAMHD1 regulates PTEN activity to influence the activation of the PI3K/AKT signaling pathway Note (A) Western blot detection of the effect of overexpressed SAMHD1 on PTEN expression; (B) IP to detect the interaction between SAMHD1 and PTEN; (C) Western blot detection of the inhibitory effect of overexpressed SAMHD1 on the PI3K/AKT signaling pathway of PTEN. Purple * indicates a significant difference compared to the oe-NC group or sh-NC + oe-NC group, with p < 0.05. Blue * indicates a significant difference compared to the sh-SAMHD1 + oe-NC group, with p < 0.05.(The data are presented as mean ± standard deviation, and an independent sample t-test was used for statistical analysis. The experiment was repeated 3 times.)