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. 2024 Oct 11;19:89. doi: 10.1186/s13062-024-00525-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — SAMHD1 knockout inhibits tumor progression by suppressing the PTEN/PI3K/AKT pathway Note (A) Tumor growth curve of HEC-1-B tumor-bearing mice; (B) Tumor size; (C) Tumor weight statistics; (D) Tunel staining for apoptosis level in tumor tissue (scale bar = 50 μm); (E) Ki67 staining for proliferation level in tumor tissue (scale bar = 50 μm); (F-G) Western blot for expression of tumor-related proteins in tumor tissue. N = 6. For multiple group data, one-way analysis of variance was conducted, with pairwise comparisons between groups analyzed using Tukey’s test. Tumor volume data at different time points were analyzed using repeated measures analysis of variance. (* in purple indicates comparison with shNC, p < 0.05; * in blue indicates comparison with shSAMHD1, p < 0.05)