Figure 6.

Cartilages engineered treated with cABC exhibit a less fibrocartilaginous, but more hypertrophic phenotype. A) In both self‐organized strategies, cABC appears to reduce the expression of collagen type I. Equally, engineering cartilage via microtissue self‐organization also reduces the expression of collagen type I, with the most pronounced accumulation noted in the D28 single‐cell group. B) All groups diffusely express collagen types II and out of the three collagen sub‐types it is the most abundant. C) Treatment of both engineered cartilages with cABC increases the expression of collagen type X. Scale bar = 700 µm (overview) and 200 µm (zoom).