Figure 9.

a) Schematic depicting the fabrication of probiotic‐encapsulated dual‐core microcapsules (top panel). These microparticles are fabricated using microfluidic chip containing two‐bore inner and outer capillaries. The goal is to simultaneously deliver two probiotics to the intestinal lumen (bottom panel). b) Quantification of IL‐10 and IL‐6 in intestine of mice treated with dual‐core microcapsule group, directly mixed probiotic microcapsule group (one‐core), empty capsule group, and a control group without any treatment. c) Therapeutic effect on preventing HFD‐induced MetS. Liver oil red O staining showing liver steatosis with different interventions. Intestinal immunofluorescence staining of gut barrier proteins, including claudin and occludin. Scale bars are 40 µm in oil red O staining and 50 µm in claudin and occludin stainings. Reproduced with permission.^{[ 125 ]} Copyright 2020, American Chemical Society.