Figure 3.

Macrophage differentiation. A) Macrophages can be recruited from circulating monocytes or from the surrounding tissue. B) Macrophages are recruited to the biomaterials earlier than tissue‐forming cells and play a crucial role in setting up the immune microenvironment that mediates the tissue regeneration process. C) Different phenotypes of macrophages are developed in response to various stimulating factors. They stain positive to distinct biomarkers and assume different functions. Produced using the cell templates from Servier Medical Art the Creative Commons Attribution 3.0 Unported License.