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. 2021 Oct 24;34(1):2100245. doi: 10.1002/adma.202100245

Figure 2.

Figure 2

A) The uptake of RuZ in six groups of parental cancer cell lines and their drug‐resistant cell lines (black grid), I: KB‐3‐1 and KB/ATO; II: BEL‐7404 and BEL‐7404/CP20; III: BIU‐87 and BIU‐87/DDP; IV: H460 and H460/MX20; V: SW620 and SW620/AD300; VI: MDA‐MB‐231 and MDA‐MB‐231/Adr. B)The subcellular distribution of ruthenium in parental and drug‐resistant cancer cells after incubation with RuZ (2.5 × 10−6 m) for 2 h. C) The efflux of drugs in MDA‐MB‐231 and MDA‐MB‐231/Adr cells after incubation with Dox (1.0 × 10−6 m) or RuZ (2.5 × 10−6 m). ***p < 0.0005. D) A schematic showing the efflux of Dox and RuZ by the efflux transporters ABCG2 and ABCB1.