Skip to main content
. 2022 Sep 13;11(22):2201626. doi: 10.1002/adhm.202201626

Figure 5.

Figure 5

The capacity of induced sweat gland cells (iSGCs) for directed functional regeneration of sweat glands (SGs). A) A schematic representation of the method, where the 3D bioprinted scaffold containing green fluorescent protein (GFP)‐labeled mesenchymal stem cells (MSCs) was transplanted in burned paws of mice. B) Iodine/starch‐based sweat test of mice treated with different cells; the presence of black dots on footpads was indicative of sweating in iSGCs‐treated mice. C) Hematoxylin and eosin staining of a plantar region with and without the cell treatment; histology results revealed SG regeneration in iSGCs‐treated mice (scale bars, 200 µm). D) Participation of GFP‐labeled iSGCs in directed functional regeneration of SG (K14, red; GFP, green; DAPI, blue; scale bar, 200 µm). E) Detection of K14, K19, K8, and K18 as SG‐specific markers in the regenerated SG tissue (arrows); (K14, K19, K8, and K18, red; GFP, green; scale bars, 50 µm). Reproduced with permission.[ 105 ] Copyright 2021, American Association for the Advancement of Science.