FIG. 5.

LZhuTRAIL reduces viral gene expression in infected cells. CD4/DR⁻ RO⁺ cells were isolated from seven HIV-1-infected patients, treated with LZhuTRAIL or agonistic TRAIL receptor antibodies (or isotype controls), and analyzed for p24 antigen production (A) and for the presence of integrated proviral DNA. (B) Viral RNA in culture supernatants. (C and D) Unfractionated cells from four HIV-1-infected patients with suppressed plasma viremia for more than 12 months were treated with or without LZhuTRAIL or agonistic MAbs to TRAIL-R2 (or isotype controls) and tested for p24 antigen (C) or viral RNA in culture supernatants (D).