Figure 1.

A) Schematic representation of the research strategy. Microtissue spheroids are fabricated by combining preset extrusion bioprinting with a microfluidic emulsification system. The microtissue spheroids with or without biomimetic structure are used for the in vivo Matrigel plug assay. B) Fluorescence image of the fabricated microparticle with (left) or without (right) structure. Green‐ and red‐fluorescent particles are used for demonstration. The intended structure is observed in “structured” particles. C) Shadowgraphic microscopy image of the fabricated particles. D) Size distribution of the fabricated microparticles. The diameter is 416 ± 26.14 µm. Coefficient of variation: 6.28%; number of samples (N): 300.