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. 2023 Feb 27;12(15):2202688. doi: 10.1002/adhm.202202688

Figure 3.

Figure 3

Control of the core forming domains enhances the micelle performance. a) Amine/phosphate distance in PEG‐PLys/dsRNA and PEG‐PGBA/dsRNA, each amine is identified by residue numbers (No.). Reproduced with permission.[ 114 ] Copyright 2021, Taylor & Francis. b) Contact surface area between PEG‐PLys/dsRNA and PEG‐PGBA/dsRNA. c) Amine/phosphate distance in PEG‐PLys/ssRNA and PEG‐PGBA/ssRNA, each amine is identified by residue numbers (No.). d) Contact surface area between PEG‐PLys/ssRNA and PEG‐PGBA/ssRNA. e) Isothermal titration calorimetry shows that the flexibility of the polycation segment affects the binding affinity to mRNA, as more flexible PEG‐PGBA binds tighter than PEG‐PLL. Reproduced with permission.[ 115 ] Copyright 2020, John Wiley and Sons. f) The remaining mRNA amount after systemic mRNA delivery by PEG‐PLys and PEG‐PGBA‐based micelles. Reproduced with permission.[ 115 ] Copyright 2020, John Wiley and Sons. g) PEG‐PGTyr enhanced mRNA delivery via π–π stacking‐assisted micellar assembly. h) π–π stacking assessment by Tyr fluorescence quenching. i) Remaining mRNA amount in the mice bloodstream after intravenous injection of mRNA‐loaded micelles. g–i) Reproduced with permission.[ 117 ] Copyright 2023, Taylor & Francis.