Skip to main content
. 2023 Feb 27;12(15):2202688. doi: 10.1002/adhm.202202688

Figure 4.

Figure 4

Micelle core stabilization by stimuli‐responsive crosslinking. a) pH‐sensitive micelle system with cross‐linked core formed by cis‐aconitic anhydride‐modified PEG‐pLL(CAA). b) Diffusion coefficient of PEG‐pLL/m and PEG‐pLL(CAA)/m versus buffer having different pHs. c) Quantification analysis luminescent signals at indicated time points. d) Bioluminescence images 9 h postinjection following in vivo delivery of naked mRNA, PEG‐pLL/m, PEG‐pLL(CAA)/m in CT26 tumor‐bearing mice. (a–d) Reproduced with permission.[ 123 ] Copyright 2022, MDPI. e) ATP‐responsive bridging between block copolymers and mRNA. Reproduced with permission.[ 112d ] Copyright 2021, Wiley‐VCH GmbH.