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Creating nanoparticles with CD8/CD3 antibody to program therapeutic T‐cells. a) T cells were programmed ex vivo to express genome‐editing proteins using a CD3‐targeted PBAE‐based mRNA polyplex. Reproduced with permission.[ 156 ] Copyright 2017, Springer Nature. b) The same system can target CD3+ cells to generate CAR‐T cells in situ, resulting in strong antitumor activity. Reproduced with permission.[ 49 ] Copyright 2020, Springer Nature.
