Figure 1.

Schematic of components and embedding process. A) Lactoprene^® 7415 reinforcement scaffolds were 3D printed using a 10% recto‐wiggle infill pattern and were combined with a HA‐TG hydrogel to form a reinforced HA‐TG. B) Compressive modulus of HA‐TG hydrogel alone and in combination with the reinforced scaffold. Data represents mean and standard deviation of n = 3 independent experiments. The p value was determined using a simple t‐test. C) Experiment timeline; in green: degradation of the lactide reinforcement material over the course of 9 weeks represented by a quasi‐linear decrease of the Young's modulus. Shaded in red: an in vitro study allowed for analysis of the material mechanically (compression testing), histologically, and by immunofluorescence (live/dead) at different timepoints. Shaded in blue: in vivo study, samples were prepared and left to preculture for 3 weeks (top row) before being implanted, while another set of samples was prepared and implanted at week 3 (bottom row). In vitro and in vivo analysis were performed at week 9.