Table 3.

Commercially available nanotechnology‐based products for sepsis diagnosis and treatment

Purpose	Name	Company	Nanocomposition	Application	Clinical stage	Ref.
Diagnosis	Verigene test	Nanosphere Inc.	Oligonucleotide‐conjugated AuNPs	Bacterial infection	Commercially available	[ 35 ]
	T2 Candida	T2 Biosystems	Oligonucleotide‐conjugated SPIONs	Blood detection for Candidemia	Clinical trial	[ 55 , 56 ]
	AbioSCOPE	Abionic SA	Nanofluidic technology	Sepsis diagnostic	Clinically validated and CE marked	[ 173 , 188 , 189 , 190 ]
	IVD Capsule PSP	Abionic SA	Nanofluidic biosensors	Quantifies PSP concentration	Clinically validated and CE marked	[ 173 , 174 , 188 ]
Treatment	Abelcet	Enzon Pharmaceutical (Sigma‐Tau Pharmaceuticals)	Liposomal amphotericin B	Fungal infection	Commercially available	[ 25 ]
	AmBisome	Gilead Sciences	Liposomal amphotericin B	Fungal infection	Commercially available	[ 87 , 189 ]
	Amphotec	Sequus Pharmaceuticals	Liposomal amphotericin B	Fungal infection	Commercially available	[ 25 ]
	Fungisome	Lifecare Innovations	Liposomal amphotericin B	Fungal infection	Commercially available	[ 26 ]
	Neulasta	Amgen Inc.	Filgrastim‐bound polymeric NPs	Fibrile neutropenia	Commercially available	[ 17 , 191 ]
	LogiCath AgTive	Smiths Medical International	Nanosilver	Antimicrobial coating device	Commercially available	[ 192 ]
	PerOssal	Aap Impantate	Calcium sulfate and nanoparticulate hydroxyapatite Composite	Antibiotic delivery	Commercially available	[ 193 ]
	Spi‐Argent	Spire Biomedical Corporation	Nanosilver	Antimicrobial coating device	Commercially available	[ 194 , 195 , 196 ]
	TAK‐242	Takeda Global Research & Development Center, Inc.	Resatorvid emulsion	Sepsis	Commercially available	[ 197 , 198 , 199 ]
	PEV7	Pevion Biotech Ltd	r‐SAP2 virosomal vaccine	Recurrent vulvovaginal candidiasis	Commercially available	[ 200 , 201 ]
	Cytosorb	CytoSorbents Corporation	Polymeric nanobeads	Hemoadsorption device for septic shock	Commercially available	[ 175 , 177 , 178 , 179 , 180 ]
	MAT2501	Matinas Biopharm	Amikacin‐loaded lipid nanocrystals	Bacterial infection	Commercially available	[ 202 ]