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Proposed principle of X‐ray mediated treatment of Alzheimer's disease (AD). a) Amyloid‐β (Aβ) misfolds and forms soluble toxic oligomers and fibrils that accumulate in the brain leading to synaptic loss and selective neuronal death. b) X‐ray irradiation of Aβ‐specific radiosensitizing nanotubes generates singlet oxygen (SO) that selectively oxidizes Aβ to inhibit aggregation and neurotoxicity, thereby preventing AD symptoms.
