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. 2024 Oct 10;20(1):2409502. doi: 10.1080/21645515.2024.2409502

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© 2024 Pfizer. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — Comparative distribution of FHbp variants in the respective MenB strain pools.

The ten most prevalent FHbp variants identified in the Pfizer MenB Collection (2000–2006) are illustrated. The prevalence of these ten FHbp variants within the Pfizer MenB Collection is compared with prevalence of the same isolates among all isolates from the contemporary PubMLST dataset (2007–2021). Cumulative percentages of these ten FHbp variants within the two strain pools were similar: they represented 76.6% of all isolates in the Pfizer MenB Collection from 2000–2006 and 72.5% of all isolates in the contemporary PubMLST collection from 2007–2021. Similarly, the overall FHbp subfamily distribution was largely unchanged: 30% from subfamily A and 70% from subfamily B among Pfizer MenB Collection strains; 34% from subfamily A and 66% from subfamily B among contemporary PubMLST strains. Nomenclatures for each variant are shown in Supplementary Table S1. FHbp = factor H binding protein; MenB = meningococcal serogroup B.