Figure 4.

Comparative PorA variant type distribution and co-expression of highly represented FHbp variants in the respective MenB strain pools.

The six most prevalent PorA variants identified in the Pfizer MenB Collection (2000–2006) are shown in the upper panel. The prevalence of these PorA variants among all MenB disease isolates from the contemporary PubMLST collection (2007–2021) is shown in the lower panel. Highly represented (n > 100) or dominant FHbp variants co-expressed with each PorA variant are shown with a non-gray color; FHbp variants less frequently co-expressed with each PorA variant are categorized as “other” and shown in gray. Nomenclatures for each variant are shown in Supplementary Table S1. FHbp = factor H binding protein; MenB = meningococcal serogroup B; PorA = porin A.