Table 1.
FHbp subfamily distribution among invasive disease isolates for each meningococcal serogroup obtained from the PubMLST dataset (2007–2021).
| Serogroup | Number (% Total) |
Number (% FHbp Subfamily A) |
Number (% FHbp Subfamily B) |
Number (% Subfamily A/B Hybrid) |
Number (% Null) |
Year of Isolation |
|---|---|---|---|---|---|---|
| MenA | 402 (2.9) | 7 (1.7) | 395 (98.3) | 0 (0) | 0 (0) | 1915–2021 |
| MenB | 6203 (45.0) | 2104 (33.9) | 4088 (65.9) | 7 (0.1) | 4 (0.03)a | 1940–2021 |
| MenC | 2125 (15.4) | 1220 (57.4) | 891 (41.9) | 4 (0.2) | 10 (0.5)a | 1965–2021 |
| MenW | 3291 (23.8) | 2391 (72.7) | 899 (27.3) | 0 (0) | 1 (0.03) | 1976–2021 |
| MenX | 105 (0.8) | 10 (9.5) | 95 (90.5) | 0 (0) | 0 (0) | 1986–2019 |
| MenY | 1673 (12.1) | 1595 (95.3) | 78 (4.7) | 0 (0) | 0 (0) | 1986–2021 |
Note: The PubMLST analysis was conducted on March 25, 2022, and retrieved 13,799 entries corresponding to unique identifications of FHbp for serogroups A, B, C, W, X, and Y. Hybrid strains have both FHbp subfamily A and subfamily B regions. Null strains lack FHbp expression.
aIncludes isolates (two MenB and one MenC) that are FHbp Pfizer “not defined” but which have an assigned FHbp peptide.
FHbp = factor H binding protein; MenA = meningococcal serogroup A; MenB = meningococcal serogroup B; MenC = meningococcal serogroup C; MenW = meningococcal serogroup W; MenX = meningococcal serogroup X; MenY = meningococcal serogroup Y.