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[Preprint]. 2024 Sep 24:rs.3.rs-4909396. [Version 1] doi: 10.21203/rs.3.rs-4909396/v1

Figure 5: Lack of antibody responses to P52, P36, and repeatless CSP proteins.

Figure 5:

a). BALB/cJ mice were gene gun primed on day 0 with a single cartridge of repeatless CSP DNA and two cartridges of P36 or P52 DNA, and then bled for sera on day 28. b). IgG serum ELISA against (i) P36 and (ii) CSP of mice given CSP/P36. Positive controls shown in S Figure 3.A. c). IgG serum ELISA against (i) P52 and (ii) CSP of mice given CSP/P52. Positive controls shown in S Figure 3.b. d). BALB/cJ mice were primed on day 0 with a single cartridge of CSP DNA and two cartridges of P36 or P52 DNA, administered 2K Py-RAS on day 28, and challenged with 10K Py-WT on day 32 as shown followed by blood collection for sera on day 62. e). IgG serum ELISA for mice immunized as in panel d against (i) P36, (ii) P52, and (iii) CSP. Positive controls shown in S Figure 3.c. N=5 mice per group. Data is from an experiment. Data are the mean ± SD.