Figure 15.

Schematic representation of the bilayered epidermal‐dermal scaffold. a) In a clinical context, the dermal component (hydrogel), containing dermal human fibroblasts, would be injected directly into the lesion. It would instantly cross‐link in situ and adapt to the shape of lesion. b) Then, the epidermal component, pre‐seeded with keratinocytes is applied on top of the dermal layer. c) Fibroblast‐containing dermal matrix (blue) and keratinocyte‐containing epidermal membrane (pink) are linked together by covalent imine bonding (amine‐aldehyde interactions). PLL and HAX abbreviations refer to poly‐L‐lysine and cross‐linked hyaluronic acid, respectively. Reproduced with permission.^{[ 116 ]} Copyright 2014, Elsevier.